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ENGINEERED ORGANIC CHEMISTRY AND THE GROWTH OF THE PHARMACEUTICAL INDUSTRY

The pharmaceutical business has developed enormously on account of various reason.

of the reasons being the help by government and non-legislative offices, quick monetary development and the most imperative of all is the enhanced condition of research centres utilized for synthetic organic chemistry and fabricate of medications.

Numerous drug specialists have a tremendous information in synthetic organic chemistry, and this is a positive pointer that the pharmaceutical business is moving a step higher. Auxiliary schools and colleges majoring in the investigation of medication have amended their syllabi and made it cover more on the issue of synthetic organic chemistry.

The development of pharmaceuticals over the globe can be said to have been directed by the mastery of the staff working in the individual organizations.

In the event that an organization has skilful staff individuals, at that point, they are probably going to fly high into the billows of success. Those with poor untrained staff will keep sinking into the remote ocean of sadness. They will keep falling into hands of legal authorities for the absence of consistency and numerous different things. Preparing is vital.

Albeit synthetic organic chemistry is not by any means the only angle that pharmaceutical organizations need to concentrate on, it should not be looked down on. Great Manufacturing Practices (GMP), is one of the strictest therapeutic administrative organization on the planet. It was set up to guarantee that all prescriptions are fabricated in understanding to globally acknowledged principles. All the great pharmaceuticals you see are because of their directions.

At long last, pharmaceutical organizations in the created nations should ascend and give some assistance to those organizations in the immature nations. This is on the grounds that the immature nations don’t have enough ability to create unrivalled quality medications. Science is sweet, so let us take pride in contemplating it constantly, and let us not have a state of mind towards synthetic organic chemistry

Molecule

Industrial peptide synthesis

Even though the structure of peptides was discovered a century ago, it wasn’t until Du Vigneaud’s synthesis of oxytocin some 50 years later that the peptide field was truly propelled and pharmaceutical usage of peptides began

Since then, this field has taken some giant leaps, and production of peptides of any size and complexity is now possible. Perhaps the most significant of all techniques was Merrifield’s publication of the solid-phase peptide synthesis (SPPS) method, which entirely revolutionized the peptide production, not only from the viewpoint of research but also because of its present widespread use for the manufacture of peptides which are used as active pharmaceutical ingredients (APIs).

Three basic strategies adopted in preparation of peptides are:-

 

  • Solution-Phase Methods
  • Solid-Phase Methods
  • Hybrid Approaches

Solution-Phase Methods

Most of the peptide pharmaceuticals presently are manufactured using solution-phase methodology. While the method can be useful for the production of longer peptides and even some small proteins, but the technique is mostly used to produce small or medium-length peptides. Products include angiotensin converting enzyme (ACE) inhibitors, Aspartame, the dipeptides sweetener, oxytocin, HIV protease inhibitors and LH-RH analogues.

 

Solid-Phase Methods

This technique is highly useful because it could be automated, leading to rapid production of quite complex sequences. Initially as the technique was proposed there were some doubts regarding to purification methods however, since increasingly powerful analytical methods and purification techniques have become available, the technique has been increasingly used for manufacturing a number of commercial products, such as LH-RH and, Somatostatin and salmon calcitonin

Hybrid Approaches

While both the solution-phase and solid-phase approaches have proven to be effective for the production of a relatively extensive variety of products, both strategies have their own limitations. With the introduction of newer resins. This has unlocked the possibility of a “hybrid” approach, in which the manufacture of complex sequences is approached through the solid-phase synthesis of large fragments, that are then assembled.

 

plant extraction

Plant extraction that beautify the world – Cosmetic products

The usage of plant extraction in the cosmetic industry is indispensable

Starting from Aloe vera to Calendula, the extracts from these plants are used in the nourishing of the skin and giving a glowing look for the people. It is these natural plant extraction that make the women to become angels.

The medicinal properties of aloe vera cannot be said in one or two paragraphs here. Its benefits in the production of skin lotions and sun burn creams are countless. The moisturizing and healing properties of the aloe vera extracts are under research and are still a topic of interest for many researchers. It is not only used in cosmetic, but also in the food industry mainly as a dessert. It has also been known for its healing properties of Pilates. However, it is less documented on this claim. Aloe vera extract, along with other plant extraction helps in the well being of the external appearance of the humans.

Close-up of vegetable juice

Extracts from Calendula on the other hand has both cosmetic and medicinal properties.

These flowers are commonly called as Marigold, which has yellow petal flowers that are used in medicinal areas. Ointments from Calendual extracts are found to be treating skin burns and radiation burns.

Another common and most widely known cosmetic herb is Acacia concinna, which is commonly called as Shikakai, traditionally meaning “Fruit for the hair”. The fruitplant extraction is used in hair care industry along with other natural extracts from long time. It is called as a traditional shampoo and have been in use from ancient times in India. Along with other natural extracts including the Indian goose berries, the plant extraction is extract forms a perfect alternative to the chemical hair conditioners. Even in the modern day of shampoos and soaps, the shikkai extract from this plant is incomparable in terms of the cooling effect it products on the head and the hair.

 

Laboratory personnel

Friedrich Wohler and the Start of Synthetic Organic Chemistry

In 1828 Friedrich Wohler discovered that he could produce urea outside the body without the production of kidney and excretion via urine

He uses inorganic starting materials, to obtain urea he treated silver cyanate with ammonium chloride. This process is the whole idea of synthetic organic chemistry, producing synthesized chemicals using starting materials either organic or inorganic compounds. The discovery led many chemists to produce and see different results, chemical reactions of combined molecules and sometimes seeing the product as medicinal also paved the way for pharmaceutical industry to broaden the list of medicines and vitamins.

Starting Materials for Synthetic Organic Chemistry

There are two different kinds of synthesizing chemicals depending on the starting materials. The very first chemistry organic, which is urea, is a total synthesis process because he used simple inorganic compounds to produce it. Production from inorganic compounds led chemists to see a new route for the targeted molecule – at this point it’s urea. They saw that it could be produced using different compounds, they also focus on seeing new chemical reactions from the by -products of it. The other process is semi-synthesis or partial chemical synthesis which uses organic compounds as a starting material to produce novel compounds with medicinal properties that later on contributed in the pharmaceutical industries. Synthetic organic chemistry is a wide range of chemically produced compounds that we can all see and study up until now.

How can an organic chemical be called synthetic as well?

 

  • First let’s understand that there is a natural organic chemical where in the chemical compounds are naturally available to us from our ecosystem and varies widely as well.
  • Synthetic organic chemistry is man-made compounds that sometimes imitates natural organic chemicals. Chemists synthesizes these chemicals to produce a synthetic organic chemicals.
  • The two origin of organic chemicals aim one thing as well and the properties are quite similar.